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Allopurinol will help prevent gout attacks only as long as you continue to take it. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole). In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. The total amount of allopurinol is usually not more than 800 mg a day.

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